glp-1 glp-2 dual agonist Rational design of dual-agonist peptides targeting and NPY2 receptors for regulating glucose homeostasis and body weight with minimal nausea and emesis Effects, working principles and target

*Correspondence: Tiziana Crepaldi, [email protected] This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

doi: 10.1063/1.448118 145 Van GunsterenWBerendsenHJ

The random error term is represented by

NAC is a natural source of sulfur for metabolism, and an antioxidant that supports glutathione synthesis.* Each tablet contains 500 mg of NAC (N-acetyl-L-cysteine)

This decline may be due to the decreased GLP-1 secretion or impairment of L-cell development [15,16,17,18]