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Lord, C

While diet should be optimised to provide a diverse array of antioxidant nutrients, supplementation may be required to address shortfalls that are common in Western-style diets

Measurement of Dnmt activity showed an increased trend in HFD-fed mice liver, and Tet hydroxylase activity significantly inversed

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It follows that, usually, the permeability and distribution of therapeutics across the AD BBB can be reduced compared to age-matched BBB in healthy subjects and this makes the BBB itself a possible therapeutic target of the disease (Banks, 2012)