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Therapeutic Approaches to Enhance GLP-1 Activity Two pharmacological strategies are available to enhance GLP-1 signalling: DPP-4 Inhibitors Mechanism: Inhibit dipeptidyl peptidase-4 (DPP-4), the enzyme responsible for degrading endogenous GLP-1

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Steady State: It takes approximately 4 to 5 weeks of consistent dosing at a single level to reach "steady state," where the amount of drug entering the body equals the amount being cleared

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