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The results in mouse models were impressive
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TGF- also enhances glycolysis, increasing the generation of 3-phosphoglycerate (3-PG), a critical intermediate that feeds into serineglycine metabolism [108, 109]
Spatial transcriptomics combined with single-cell RNA sequencing identified high expression levels of ferroptosis-related genes, including TFRC, NCO4, and SLC3A2, in granulosa cells of patients with ovarian senescence, while GPX4 expression was notably low (Lin et al., 2023)
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