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The Biology Project, Department of Biochemistry and Molecular Biophysics, University of Arizona

L-arginine supplements are generally not recommended for people who have: kidney disease low blood pressure (hypotension) guanidinoacetate methyltransferase deficiency, an inherited condition that impacts arginine metabolism L-arginine may also interact with medications like those used to treat high blood pressure

Shah, T

These genetic variants don't determine your exact medication response, but they can inform a more nuanced dosing conversation with your provider, potentially helping you avoid unnecessarily high doses or side effects

Increase dose gradually