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Ethical review by an ethics committee was not applicable as this article is based on previously conducted studies and direct observations from real-world clinical practice

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Mechanistically, oxidative stress activates p16-pRb effector pathway which is thought to play a vital role in SIPS mediation 11

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5 Metformin promotes apoptosis of glioma cells Metformin has recently gained attention for its potential antitumor effects, particularly in various cancer types, including glioblastoma (60)

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Mayneris-Perxachs J, Castells-Nobau A, Arnoriaga-Rodrguez M, et al

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