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When caloric intake drops too quickly or becomes inadequate to meet metabolic needs, fatigue naturally follows

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These vasodilatory mechanisms are diverse but share two distinct characteristics in that the activity of each of the differing mechanisms increases in direct response to increasing intensities of exercise and those mechanisms all initiate the synthesis of nitric oxide (NO)

Water-soluble antioxidants (GSH, vitamin C) are active in the cytosol and plasma, while lipid-soluble antioxidants (vitamin E, carotenoids) localize to membranes (20)