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The effectiveness of GLP-1 receptor agonists in menopausal women is shaped by the broader hormonal environment within which they operate: whether estrogen has been restored, whether progesterone is supporting sleep quality and endometrial health, and whether testosterone decline is accelerating the muscle loss that weight reduction can compound
The difference likely relates to individual metabolic factors we do not yet fully understand
The magnitude of weight loss with semaglutide and tirzepatide places pharmacotherapy into a category that previously would have only been associated with surgical intervention
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