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Lending support to this hypothesis, a recent imaging study demonstrated that GLP-1 reduces activity in parts of the brain involved in appetite and reward in people with Type 2 diabetes and obesity

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Edited by Lin LY, Lei Y Acknowledgements The authors would like to thank to Universitas Hasanuddin for providing financial support under Penelitian Fundamental Kolaboratif (PFK) (00323/UN4.22/PT.0103/2023), and highest appreciation to the National Research and Innovation Agency (BRIN) and World Class University Program, Indonesia Endowment Fund for Education, Universitas Diponegoro

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Taken together, these findings demonstrate that gut microbiota and their metabolites exert dual and context-dependent effects on GLP-1 secretion and signaling