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Weight loss often improves these markers, so baseline measurements help track progress and cardiovascular benefits

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A meta-analysis involving more than 70,000 participants with type 2 diabetes (SMART-C) found that the cardiovascular benefits of SGLT-2 inhibitors, including reductions in MACE, cardiovascular death, hospitalisation for HF, and CKD progression, were consistent regardless of whether patients were receiving a GLP-1 receptor agonist at baseline [19]

A chimeric receptor approach has been used previously by other groups to define the different regions of the glucagon family of GPCRs responsible for their selective binding of, and activation by, their endogenous ligands (Xiao et al., 2000