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Pregnancy and lactation represent relative contraindications given absence of human safety data in these populations despite reassuring preclinical reproductive toxicology studies

Same warnings apply to both Both carry warnings around thyroid C-cell tumors (seen in animal studies), pancreatitis, and gallbladder issues, based on their shared hormone-receptor mechanism

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Pancreatic and Other Cancer Types: Safety Data Concerns about pancreatic cancer and pancreatitis associated with GLP-1 medicines emerged from early case reports and theoretical mechanisms