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Journal of Clinical Investigation
However, research also indicates that it impacts parts of the brain that will suppress an appetite and signal that the body is full
Evolocumab belongs to the class of medications called PCSK9 inhibitors
Sitagliptin, a dipeptidyl peptidase-4 inhibitor, was selected as an active-comparator placebo proxy because it was recommended in clinical guidelines as a second-line glucose-lowering therapy, had a similar high cost to the study drugs, showed no effect on cardiovascular outcomes in a large randomized controlled trial and has been validated as a placebo proxy in prior claims-based research 20,41
Analysis showed that the trial met its primary endpoint of achieving a superior mean percent change in body weight with tirzepatide versus placebo from week 36 to week 88, with patients sustaining weight loss
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