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The substantial weight loss achieved with GLP-1 receptor agonists and dual GIP/GLP-1 agonistsapproximately 15% with semaglutide 2.4 mg (Wegovy) and up to 21% with higher doses of tirzepatide (Zepbound) in clinical trialsoccurs primarily through appetite suppression and reduced caloric intake rather than increased metabolic rate
Holistic Integr Oncol
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It mediates important physiological effects of the endogenous peptide, GLP-1, in regulating insulin secretion, carbohydrate metabolism and appetite, and thus is well established as a long term clinical target for treating type II diabetes and obesity (Graaf et al
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