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Collectively, the functional states of macrophages extend beyond the simplistic M1/M2 framework, forming a multidimensional continuum shaped by signaling networks, epigenetic regulation, and metabolic reprogramming, which profoundly influences their diversity and adaptability in both physiological and pathological contexts

Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia

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