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nternational Journal of Molecular Science, 14

When to reach out to your Care Team: If constipation lasts more than three days If it is accompanied by nausea, vomiting, or abdominal pain Seek immediate medical care if you experience severe pain, bloating with an inability to pass gas, or ongoing nausea and vomiting

And I think the problem with sleep is you know trying to sleep can actually make you not sleep in a way, its one of those few areas where sort of letting go its actually more of the key than trying harder

For patients with a healthy GI tract, this is the desired effect

2 GLP-1 receptors are expressed in brain regions involved in satiation, satiety, and reward, including the hypothalamus, brainstem, and mesolimbic pathways