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A practical starting approach: Week 1: Start with a high-quality hemp oil extract matched to your dog's size Week 3: Add an omega-3 supplement (or choose a hemp formula with a krill oil base to cover both) Week 5: Introduce turmeric/curcumin or a multi-compound formula like Tucker's Gold Week 7: Evaluate progress and consider adding boswellia, GLM, or MSM if needed Throughout, pair supplements with weight management (the single most impactful lifestyle change for an arthritic dog), consistent low-impact exercise , and an anti-inflammatory diet rich in omega-3s and antioxidants

Vitamin B12 is crucial for its role in DNA synthesis, normal brain function, and red blood cell production

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Cellular studies have shown that exogenous NAD + can impact mitochondrial activity, such as boosting Krebs cycle and the ETC, but also impair genomic DNA replication and induce DNA replication stress due to impairment of pyrimidine biosynthesis 118

Wang JZ, Wu Q, Smith A, Grundke-Iqbal I, Iqbal K