At the highest doses, retatrutide seems to promise more significant weight loss than existing GLP-1s on the market but as dosage increases, so does the risk of side effects, mostly mild-to-moderate gastrointestinal issues, although one case of pancreatitis occurred in a patient on the 12mg dose during the phase II trial
Zepbound is an injectable prescription medicine that, used along with a reduced-calorie diet and increased physical activity, may help adults with obesity, or with excess weight (overweight) who also have weight-related medical problems, lose weight and keep it off
If you've achieved meaningful weight reduction (typically 5-10% reduction) at 7.5 mg with minimal adverse effects, escalating to 10 mg often produces additional benefit
Its a completely fair question
In central sensitization, the spinal cord and brain amplify incoming signals regardless of their original intensity