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Gastric juice contents assessment To eliminate any solid debris, the stomach juice obtained from each animal was subjected to centrifugation at 3000 revolutions per minute for 10 min

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In Phase 3 clinical trials (REDEFINE 1 and REDEFINE 2), the cagrilintide and semaglutide combination was administered once weekly via subcutaneous injection, with dose escalation targeting 2.4 mg of each peptide weekly over a 68-week trial duration