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By stimulating the endogenous secretion of insulin, reducing the production of glucagon, and delaying gastric emptying, GLP1AR reduce glucose levels and enhance metabolic control
Retatrutide is also a 39 amino acid modified GIP molecule, but with changes to the amino acid structure to allow for activity at the GCGR site to achieve triple agonist activity at the GLP-1R, GIP-R, & GCGR
When it comes to weight loss medications, tirzepatide and semaglutide are two of the most talked-about options today
The choice of alternative therapy depends on individual patient factors including renal function, cardiovascular risk profile, weight management goals, hypoglycaemia risk, and patient preferences, all of which should be discussed thoroughly with the GP or diabetes specialist team
The Pros of Semaglutide: Effective Weight Loss: Clinical trials have demonstrated that Semaglutide can lead to substantial weight loss
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