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Given that both ME/CFS patients and GWS models exhibit elevated levels of oxidative stress, the symptom improvement observed with oxaloacetate treatment may be attributable to its capacity to reduce oxidative stress (Gottschalk et al., 2022

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Much of the current evidence comes from laboratory and animal studies, which are encouraging but are not a substitute for large, long-term human clinical trials

Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression

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