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Imaging studies, where employed, may show tissue changes during mid-phase
Further studies have confirmed that both dietary serine supplementation and genetic PHGDH overexpression effectively drive malignant progression of melanoma by elevating intracellular serine levels ( Evidence also suggests that PHGDH regulates the brain metastasis of melanoma
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Compression stockings, slower postural changes, and blood pressure monitoring are effective adjunct strategies, but sodium and fluid management address the root cause and should be implemented first before considering dose reduction
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