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In the presence of a peptide bond, it is only the backbone carbonyl that is functional
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Sderlund J, Olsson SK, Samuelsson M, Walther-Jallow L, Johansson C, Erhardt S, et al
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65 Deficient CDO activity has been related to lower sulphate levels in plasma, elevated fasting plasma cysteine concentrations, and lower sulphate-conjugate:glucuronide-conjugate ratios for paracetamol detoxification products, consistent with impaired cysteine catabolism
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