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Moreover, GLP-1RA reduced the risk of MACE by 14% in the overall diabetic population, with an apparent greater effect in patients with established CV disease (16% vs 6% reduction, respectively), although the lack of significant interaction between subgroups does not allow to separate them [12]
They investigated both anti-diabetic medications with weight loss-inducing effects, including semaglutide, dulaglutide, liraglutide, tirzepatide, empagliflozin, canagliflozin, dapagliflozin, and metformin, as well as other weight loss-inducing drugs, including orlistat, phentermine, bupropion, topiramate, zonisamide, amphetamine, and naltrexone
(2026), in the American Journal of Sports Medicine, stated this directly: indications, dosing, frequency, and duration of treatment remain unknown
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