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Cysteine requires two more enzymatic reactions before being finally converted into glutathione
Finkelstein, Y
E3 ubiquitin ligases such as Hrd1 play a central role in targeting misfolded ER proteins for degradation
We believe that this limited contribution and non-essentiality of caspase-3 for the execution of eryptosis is associated with the absence of the upstream mitochondrial pathways in mature erythrocytes linked with the expulsion of this particular organelle at the terminal stages of erythropoiesis, as well as downstream effectors
