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centrally-mediated loss of appetite & increased thermogenic activity GLP-1 receptors are found in regions of the hindbrain and hypothalamus that regulate feeding behavior Centrally mediated GLP-1 effects include: reduction of food intake - resulting in weight loss due to reduced caloric intake activation of sympathetic pathways in the dorsomedial hypothalamus (DMH) and ventromedial nucleus of the hypothalamus (VMH) that increase neuronally mediated thermogenic activity of brown adipose tissue (BAT) resulting in increased energy expenditure with associated weight loss (Contreras et al, 2017
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Physiol Rep 3(11):e12610 Acosta A, Camilleri M, Shin A, Vazquez-Roque MI, Iturrino J, Burton D et al (2015b) Quantitative gastrointestinal and psychological traits associated with obesity and response to weight-loss therapy
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