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[20] [21] Nevertheless, the rapid weight loss associated with GLP-1 therapy, particularly at higher doses used for obesity management, has prompted ongoing investigation into potential indirect effects on skeletal health, particularly in populations already at risk for osteoporosis
However, physiological does not mean inevitable
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No prospective studies have been conducted in humans in controlled circumstances to demonstrate whether CYP450 polymorphisms lead to an increase or a decrease in paracetamol oxidation nor have there been studies demonstrating that CYP450 polymorphisms in humans increase or decrease the risk of paracetamol toxicity before or after an overdose