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The aggressive biological characteristics of CSCs are supported by a complex interplay of various signaling pathways, suggesting the potential importance of focusing on traditional pathways in the treatment of CSCs

In the clinic, GLP-2 analogs are mainly administered by subcutaneous injection, and patient compliance is poor, so this experiment chose the DPP-IV inhibitor sitagliptin to indirectly increase the level of GLP-2 by gavage in mice, and for the administration of sitagliptin, the following points are explained: Intraperitoneal injection is the injection of the drug into the animal's gastrointestinal tract outside the plasma membrane and within the peritoneum and is generally used for administration where absorption through the gastrointestinal tract is inappropriate or less efficient

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To avoid the side-effects becoming unmanageable, we need to start taking the medication in small doses and slowly increase until we are at the top (maintenance) dose

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