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"Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma"
Circulation 107(25):31333140
Agonist-modulated palmitoylation of endothelial nitric oxide synthase
Check at baseline, 6-8 weeks after starting, after each 10-15 pounds of weight loss, every 3-4 months during active weight loss, and every 6 months after weight stabilization
People with high insulin resistance (ie, people with obesity), young age at dysglycaemia, abnormal 1 h glucose concentrations (86 mmol/L) despite normal 2 hr glucose concentrations on 75 g oral glucose tolerance test, and low C-peptide are at higher risk for progressing to stage 3 (fast progressor, stage 2b) than those diagnosed with dysglycaemia after age 65 years (slow progressor, stage 2a)
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