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A tendon problem may involve inflammation, degeneration, partial tearing, poor mechanics, inadequate recovery, medication exposure, metabolic health, or another underlying issue

Studies in hundreds of participants have found that higher blood levels of 1-methylnicotinamide (a marker related to NNMT activity) correlated with greater NNMT in adipose tissue, and were inversely related to insulin sensitivity

Animal studies show that mice prone to obesity have high NNMT levels in their white fat tissue