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It is possible that compensatory mechanisms could develop that reduce efficacy with prolonged use

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These are the B complex vitamins, including Vitamin B12: Vitamin B1 or thiamine Vitamin B2 or riboflavin Vitamin B3 or niacin or nicotinic acid Vitamin B5 or pantothenic acid Vitamin B6 or pyridoxine, pyridoxal or pyridoxamine Vitamin B7 or biotin Vitamin B9 or folic acid Vitamin B12 or cobalamins such as cyanocobalamin or methyl-cobalamin While all the Vitamin B100 Complex vitamins are chemically different, several can be found together in food sources

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