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NICE guidance on obesity management (CG189) emphasises evidence-based interventions including dietary modification, increased physical activity, behavioural therapy, andwhere appropriatepharmacotherapy with licensed medications such as orlistat or semaglutide (NICE TA875)

What is not normal is a reaction that is severe, that gets worse rather than better over two to three days, or that involves your chest, breathing or a spreading rash

As a peptide fragment, behaviour may differ from full-length growth hormone in receptor or signalling assays

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