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These findings align with our plasma biomarker analyses demonstrating reduced plasma levels of the cytokines tumour necrosis factor and MCP-1 in CNS GIPR KO mice, as well as existing literature showing that GLP-1R agonists targeted to CNS GLP-1R have anti-inflammatory effects 20

Pro-inflammatory cytokines, including TNF-alpha, show reduced expression in BPC-157-treated models, limiting the duration of the acute inflammatory phase that delays tissue remodeling

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Additionally, Semaglutide may indirectly improve joint health by reducing systemic inflammation