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And there is a countervailing consideration the frequency logic tends to omit: more frequent stimulation of the ghrelin receptor raises the theoretical prospect of desensitization over time, so more pulses per day is not straightforwardly more effect, even on the models own terms

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A phase IIA study of atorvastatin showed a significant reduction in mycobacterial load in the sputum of patients with pulmonary tuberculosis (PTB) [61], while another trial using rosuvastatin did not affect sputum culture conversion [62]

Both are early enough in development that the published endpoints are surrogates body weight, HbA1c, liver fat measured over trial-length follow-up