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Compare this to oral supplements, where even high-dose pills achieve only about 1.3% absorption due to limitations in your digestive systems intrinsic factor production

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Initial response time also depends on: Severity of the B12 deficiency Frequency of injections Underlying health conditions Absorption and metabolism differences If youre getting your first B12 shot, your provider may start you on a more aggressive schedule, such as weekly injections until your levels are normalized

Other antibiotics such as cycloserine and penicillamine have similar vitamin B-antagonizing effects, necessitating supplementation to avert neurological side effects

Regulating Homocysteine Levels: High homocysteine is a common issue for those with an MTHFR mutation, and elevated levels are associated with a higher risk of cardiovascular disease