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DSIP has been described as influencing GABA-A receptor activity in a way sometimes compared to benzodiazepines but, importantly, without the sedation or dependence profile associated with those drugs

Furthermore, multiple studies have demonstrated that heat stress-induced spermatogenic dysfunction 209 is closely associated with germ cell apoptosis, which displays both cell-type- and stage-specific 210 characteristics (Figure 1c) (Lue et al., 1999

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Theoretical Concerns From Mechanism While NNMT inhibition is a promising research target, the mechanism raises points that warrant caution in interpretation

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