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It's not an easy switch but there are some patients, perhaps those who could benefit from losing 6-8%, who have tried other means and might benefit
A GLP-1R agonist (liraglutide) increased endothelial nitric oxide synthase phosphorylation and nitric oxide (NO) production by the 5-AMP-activated protein kinase (AMPK)-dependent pathway and subsequent NO production in cultured HCAEC [56],[57]
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