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Dose and titration speed are among the most significant determinants

Intestinal absorption and cellular transport depend on transporters (e.g., OCTN2 ) and the kidney reabsorbs much of it to maintain levels

Accordingly, we combined the most effective reversion positions with Glu72Arg and applied them to the X(GD_L)aX(GD_L)c background to generate X(GD_L)dX(GD_L)f (Fig