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In a set of proof-of-principle experiments, we measured gut permeability ex vivo in response to luminal introduction of EGTA, a calcium chelator that disrupts TJ integrity and paracellular barrier functions (confirmed using dynamic TEER assay (Fig

Retatrutide (LY3437943) is an investigational triple receptor agonist (GLP-1, GIP, and glucagon) studied for obesity and metabolic outcomes

For these localized applications, systemic absorption may matter less than direct contact with digestive tissues

Syringe handling: Use a separate syringe for each compound when running separate vials

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