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Lilly's Kinsale facility, recognised as ISPE's 2024 Overall Facility of the Year, uses a hybrid SPPS/LPPS platform in which SPPS builds pre-assembled peptide fragments of six to fourteen amino acids, and liquid-phase peptide synthesis (LPPS) then couples those fragments together using continuous processing, with parallel fragment production at multiple global supply nodes creating supply chain resilience that purely centralised batch manufacturing cannot provide
Chaudhry A, Gabriel B, Noor J, et al
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Severe or ongoing dehydration can lead to serious or possibly fatal complications
Also at kidney level, RAS compartmentalization and independent regulation have been shown to play an important role in the pathogenesis of hypertension and diabetic nephropathy (36)
