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They should mainly be used as second-line therapy as add on to metformin in patients with type 2 diabetes who have no pre-existing cardiovascular disease and have a therapeutic goal to avoid hypoglycaemic events

These agents act through multiple mechanisms, including direct cardioprotection, vasodilation, natriuresis, weight reduction, lipid profile improvement, anti-inflammatory effects, renal protection, reduction in plaque formation, and neurohormonal regulation [50]

Do not use it if it looks cloudy, discolored, frozen, or has floating particles

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