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A 2025 study published in The Lancet Diabetes & Endocrinology found that a 7.2-milligram dose of semaglutide led to an average of 3% greater weight loss over 72 weeks compared with the 2.4-milligram dose

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This table helps patients understand which symptoms may be mild and which symptoms should be reviewed by a provider

Some providers extend dosing beyond standard ranges in clinical research settings, though off-label escalation requires careful monitoring and clear informed consent

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