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Slightly more nerdy answer: because peptides are small, they can bind directly to cell receptors and trigger specific biological effects
Vitamin B 12 deficiency can lead to anemia, neurologic, and digestive dysfunctions
doi:10.1186/1471-2105-7-351
Notably, in vivo reduction of lactate production or inhibition of GPR81-mediated signaling pathways significantly decreases circulating exosomal HMGB1 levels, thereby improving survival outcomes in polymicrobial sepsis [28]
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