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Gradual Dose Escalation Gradual dose escalation proceeds with: Weeks 1-4: 1 mg once daily Weeks 5-8: 2 mg once daily Thereafter: Adjustment based on individual response and goals Dosing Frequency Options Dosing frequency most commonly involves once daily administration (morning or evening), with alternative protocols using 2-3 times per week at 2 mg per injection

Patio-Cardona, S., Garrido-Miguel, M., Pascual-Morena, C., Berlanga-Macas, C., Lucern-Lucas-Torres, M., Alfaro-Gonzlez, S., & Martnez-Garca, I

It is important to note that anyone who utilizes the information contained within this protocol should do so in collaboration with their oncology team

V., Jnior, G

xii Data on file