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Clinical data from the STEP trials shows clear dose-dependent increases in side effects
Source Reference: Bliddal H, et al "Once-weekly semaglutide in persons with obesity and knee osteoarthritis" N Engl J Med 2024
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The strongest human evidence is short-term endocrine pharmacology: GHRP-2 reliably and rapidly releases growth hormone, synergizes with GHRH, and works well enough as a GH-stimulation test to be an approved diagnostic agent in Japan
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