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doi:10.1056/NEJMoa2032183 Pi-Sunyer X, Astrup A, Fujioka K, et al
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Indeed, age-related declines in skeletal muscle mass index (SMI) and function often occur in parallel with increases in total FM, while the clinical course of obesity is characterized by a range of risk factors for sarcopenia, including elevated oxidative stress, inflammation, and the burden of NCDs [15, 16]
Neuromodulation Although FAO is not a major pathway in brain bioenergetics, carnitine still accumulates in the brain, and in neurons isolated from the adult brain, about 80% of total carnitine remains in free form, while about 1015% is present as acetylcarnitine and about 10% as LCACs [90]
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