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A consistent estimation of the causal effect can be obtained using the weighted median method if the weighted median of the SNP-specific estimates reaches 50% ( p -values below 0.0012 (0.05/42) as indicating strong evidence of associations in the MR analysis between the six endogenous antioxidants and six cancers

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Following this pattern, the dose progresses to 1mg, then 1.7mg, and finally reaches the maintenance dose of 2.4mg weekly

Zhang J, Willers H, Feng Z, Ghosh JC, Kim S, Weaver DT, et al