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Sure, it doesnt fully remove a creature, and that can be a liability sometimes and there are lots of ways your opponent can get around this card like by bouncing their creature

It is always a lot of fun

If you want to try something a little different, you could opt for a Toughness Matters secondary strategy using High Alert or Vent Sentinel and a whole bunch of Defenders

Regarding EX cards, there's nothing written on them about limiting them to one per deck so this rule from rulebook applies [1] : When you are building a deck, you can have only 4 copies of a card with the same name in it, except for basic Energy cards

Its important to note that regeneration only replaces destruction